Cant say about the AWD but I have run 17" Yoko Avid XL's on our FWD, without any tangible benefit with tire life. It is a daily drive with two adults so really not pulling that extra load. They wore eually fast as the SL rated tires. Car rated tires just wont cut it on the heavier chassis of a Sienna as far as tire's rated life is concerned. Your best bet is to go with a Crossover/SUV rated tires.