Just got back from a trip to upstate NY from SE PA. Just under 600 miles RT in a 2004 Sienna LE AWD with @96,xxx miles on it. Mostly interstate miles, got a bit over 24 MPG. Tried to keep it about 67 mph give or take. Used cruise when possible. I did take off the run flats and installed regular tires and now have a spare in the back.