The Car Care Nut Channel guy, Ahmed, has done videos and has discussed when it's too late to do a change of fluid. It's an absolute that you don't flush it, it's strictly a drain and fill, but at 110,000 miles, it may be past a good, safe threshold. I would imagine that the gentler it has been driven, the safer it probably is to do a drain and fill. Not knowing exact capacities on yours, when I've done that job on two Toyota automatic transmissions about 25% - 30% of the fluid passively drained. I also let it drain a lot longer on both jobs. So I may have gotten substantially more by letting it drip for hours.
I've done a fluid change at 64,000 miles on a U760E 6-speed RAV4 transmission, I sent some fluid in for testing and they said it had less than 10% life left. That particular car was 90% freeway although it would regularly hit California traffic. One of the used RAV4s we bought had an ATFWS drain and fill at 98,467 at a dealership. Everything is great with that transmission now that it's at 122.5k.
Since the Sienna shouldn't be driven like a race car, that extra weight on that transmission shouldn't be too much of a stretch. Regular hard acceleration though may change that...